The role of the complement system in the pathogenesis of age-related macu-lar degeneration and recent advances in targeted complement therapy
10.13389/j.cnki.rao.2025.0143
- VernacularTitle:补体系统在年龄相关性黄斑变性发病机制中的作用及靶向补体治疗的研究进展
- Author:
Jia GAO
1
;
Mengdi ZHANG
1
;
Wenjia QU
1
;
Ya MO
1
Author Information
1. 610000 四川省成都市,成都中医药大学附属医院眼科;610000 四川省成都市,成都中医药大学眼科学院
- Publication Type:Journal Article
- Keywords:
age-related macular degeneration;
complement system;
inflammation;
oxidative stress;
treatment
- From:
Recent Advances in Ophthalmology
2025;45(10):830-834
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration(AMD)is a chronic degenerative retinal disease that severely impairs pa-tients central vision.Research indicates that the complement system is closely associated with the onset and progression of AMD,playing a key role in its pathogenesis,involving various factors such as genetic risk,inflammatory responses,and oxidative stress.This review summarizes the relationship between complement system activation and AMD,as well as re-cent clinical trials targeting complement-based therapies for AMD,with the aim of providing insights for both basic research and clinical treatment of AMD.
