Research progress on the role of the NF-κB signaling pathway in neovascular age-related macular degeneration
10.13389/j.cnki.rao.2025.0142
- VernacularTitle:NF-κB信号通路在新生血管性年龄相关性黄斑变性中的作用研究进展
- Author:
Limin ZHANG
1
;
Gang ZOU
;
Shuo SUN
;
Qianhui YANG
;
Boshi LIU
;
Xiaorong LI
Author Information
1. 300384 天津市,天津医科大学眼科医院、眼视光学院、眼科研究所,国家眼耳鼻喉疾病临床医学研究中心天津市分中心,天津市视网膜功能与疾病重点实验室;010100 内蒙古自治区呼和浩特市,内蒙古医科大学附属医院眼科
- Publication Type:Journal Article
- Keywords:
neovascular age-related macular degeneration;
NF-κB signaling pathway;
oxidative stress;
inflammatory response;
angiogenesis
- From:
Recent Advances in Ophthalmology
2025;45(10):825-829
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration(AMD)is one of the leading causes of blindness in the elderly.Wet AMD(nAMD)accounts for more than 90％of AMD-related vision loss.Pathologically,nAMD is defined by choroidal neovascu-larization(CNV)and chronic retinal inflammation driven by oxidative stress,complement activation,pro-inflammatory cy-tokines,and overexpression of vascular endothelial growth factor(VEGF).Yet anti-VEGF monotherapy often falls short.The nuclear factor kappa-B(NF-κB)signaling cascade,acting through both canonical and non-canonical pathways,or-chestrates the expression of genes governing immunity,inflammation,apoptosis,and angiogenesis.In nAMD,oxidative stress and complement fragments ignite NF-κB,unleashing a repertoire of pro-inflammatory and pro-angiogenic mediators that fuel CNV.Pharmacologic or genetic suppression of NF-κB dampens both inflammation and neovascularization,attenua-ting experimental CNV.Thus,dissecting the molecular machinery of NF-κB signaling in nAMD may uncover novel combina-tion strategies that enhance therapeutic efficacy and curb anti-VEGF resistance.
