Study on the Causal Association between the Body Mass Index and Transfusion Reactions Based on Mendelian Randomization
10.3969/j.issn.1671-7414.2025.06.027
- VernacularTitle:基于孟德尔随机化研究体重指数与输血反应的因果关联
- Author:
Suliang LI
1
;
Zhe WANG
;
Bing LIU
;
Xiaohua YUAN
;
Hongqin LU
;
Dan WANG
;
Yan JING
;
Yun YE
Author Information
1. 西安医学院第一附属医院 输血科,西安 710077
- Publication Type:Journal Article
- Keywords:
bady mass index;
mendelian randomization;
transfusion reaction
- From:
Journal of Modern Laboratory Medicine
2025;40(6):149-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aimed to examine whether body mass index(BMI)was causally associated with blood transfusion reactions.Methods A two-sample Mendelian randomization(MR)analysis using the inverse variance weighted(IVW),MR-Egger regression,weighted median method(WME),weighted model method(WM),simple model method(SM)and simple median method(SM)was performed.Public genome-wide association study(GWAS)analysis was used as the data source,with summary statistical data sets of BMI(n=126 003;GWAS ID:ebi-a-GCST90095042)as the exposure variable and summary statistical data sets of transfusion reactions(n=199 451;GWAS ID:finn-b-ST19)as the outcome variable.The causal association between BMI and transfusion reactions was analyzed.Results 42 single nucleotide polymorphisms associated with transfusion reactions were identified by MR analysis.The IVW showed evidence to support the causal relationship between BMI and transfusion reactions(OR=0.29,95%CI=0.10～0.85).Nonetheless,the effect value β of the MR-Egger regression approach contrasts with that of IVW.The outcomes of the heterogeneity analysis,pleiotropy analysis,and sensitivity analysis indicated that P>0.05.Conclusion The results of MR analysis supported the possibility of a causal relationship between BMI and blood transfusion reactions,that is,the reduction of BMI will increase the risk of blood transfusion reactions.
