Comparative analysis of perinatal outcome of intracytoplasmic sperm injection and frozen-thawed embryo transfer between donor and autologous oocytes
10.3760/cma.j.cn101441-20210514-00217
- VernacularTitle:应用赠卵与自卵行ICSI-FET助孕的围产期结局的比较分析
- Author:
Chen YANG
1
;
Wei ZHENG
1
;
Shuheng YANG
1
;
Mingkun MU
1
;
Simin SUN
1
;
Bingnan REN
1
;
Ruowen ZU
1
;
Shiyu RAN
1
;
Huan WU
1
;
Yihui KUANG
1
;
Caixia ZHANG
1
;
Yichun GUAN
1
Author Information
1. 郑州大学第三附属医院生殖医学中心，郑州 454000
- Publication Type:Journal Article
- Keywords:
Sperm injection, intracytoplasmic;
Frozen-thawed embryo transfer;
Oocyte donation;
Autologous oocyte;
Perinatal outcome
- From:
Chinese Journal of Reproduction and Contraception
2022;42(5):462-468
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the obstetric outcomes of intracytoplasmic sperm injection and frozen-thawed embryo transfer (ICSI-FET) between donor and autologous oocytes.Methods:A retrospective cohort study was conducted to analyze the clinical data of pregnant patients who underwent ICSI-FET in the Reproductive Center of the Third Affiliated Hospital of Zhengzhou University from June 2016 to January 2020. Totally 73 patients with donor oocytes, and 550 patients who used autologous oocytes in the same period, and the patients were matched at 1∶3 with propensity score matching (PSM), then there were 47 patients in donor group and 131 patients in autologous group. The general conditions and obstetric outcomes were compared among donor group and autologous group. Multivariate logistic regression and linear regression were applied to analyze the factors affecting perinatal complications.Results:The bilateral antral follicle count (3.08±4.78) and basal estradiol level [(71.55±45.29) pmol/L] in donor group were significantly lower than those in autologous group [14.95±6.42, (132.84±74.89) pmol/L, all P<0.001]. The birth weight of singleton in donor group [(2 916.48±537.55) g] was lower than that in autologous group [(3 326.67±503.43) g], and there was significant difference ( P<0.001). There were no significant differences in premature birth rate [21.28% (10/47) vs. 16.03% (21/131), P=0.416] and incidence of hypertensive disorder complicating pregnancy [12.77% (6/47) vs. 7.63% (10/131), P=0.448] between donor group and autologous group, but both of them had an increasing trend in donor group. Oocyte-donated ICSI-FET reduced the birth weight of singleton (MD=-388.225, 95% CI=-625.914--150.537, P=0.002). Conclusion:The perinatal outcome of oocyte-donated ICSI-FET is relatively safe, but the birth weight of singleton is lower than that of self-oocyte ICSI-FET.
