The clinical value of baseline 18F-fluorodeoxyglucose PET/CT in predicting the prognosis of diffuse large B-cell lymphoma
10.3969/j.issn.1002-1671.2025.09.030
- VernacularTitle:基线18F-氟脱氧葡萄糖PET/CT预测弥漫性大B细胞淋巴瘤预后的临床价值
- Author:
Liu HE
1
;
Cheng GU
;
Bin HU
;
Guoquan WANG
;
Xiaoming ZHANG
;
Lichun ZHENG
Author Information
1. 唐山市工人医院核医学科,河北 唐山 063000;华北理工大学研究生学院,河北 唐山 063000
- Publication Type:Journal Article
- Keywords:
diffuse large B-cell lymphoma;
tumour-to-liver blood pool maximum standardized uptake value ratio;
positron emis-sion tomography/computed tomography;
18F-fluorodeoxyglucose;
international prognostic index
- From:
Journal of Practical Radiology
2025;41(9):1557-1561
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of baseline 18F-fluorodeoxyglucose(18F-FDG)PET/CT metabolic parame-ters and certain clinical indicators in predicting the prognosis of patients with diffuse large B-cell lymphoma(DLBCL).Methods A retrospec-tive analysis was conducted on the baseline 18 F-FDG PET/CT data of 73 DLBCL patients who received R-CHOP treatment.Patients were divided into progression group(24 cases)and non-progression group(49 cases)based on disease progression within 2 years post-treatment.The lesion maximum standardized uptake value(SUVmax),tumour-to-liver blood pool SUVmax ratio(LLR)and tumour-to-mediastinal blood pool SUVmax ratio(L-BPR)were analyzed using receiver operating characteristic(ROC)curves.Kaplan-Meier(K-M)survival curves analysis were performed based on the optimal thresholds of SUVmax,LLR and L-BPR.x2 tests were used to analyze and compare the relationship between each parameter and disease progression.Indicators that were significant in the x2 tests were included in the multivariate Cox regression analysis.Results The area under the curve(AUC)for LLR,L-BPR,and SUVmax were 0.920,0.914,and 0.848,respectively,with optimal thresholds of 7.41,10.67,and 14.70.Based on these thresholds,K-M survival curves analysis showed that the 2-year progression-free survival(PFS)rates for DLBCL patients were 79.2％vs 30.8％(P＜0.001),74.3％vs 22.0％(P=0.009),and 79.5％vs 51.6％(P=0.002),respectively.Significant differences were observed between the progression and non-progression groups in terms of LLR,L-BPR,SUVmax,extranodal involvement,international prognostic index(IPI)score,lactate dehydrogenase(LDH)level,Eastern Cooperative Oncology Group(ECOG)score,and β2-microglobulin(β2-MG)levels(P＜0.05).Multivariate Cox regression analysis revealed that the IPI score and LLR were independent predictors affecting the 2-year PFS of DLBCL patients(P＜0.05).Conclusion Baseline 18F-FDG PET/CT metabolic parameter LLR and IPI score are inde-pendent factors for predicting the prognosis of DLBCL patients.
