The correlation between sarcopenia and anastomotic leakage after rectal cancer surgery
10.3969/j.issn.1002-1671.2025.09.016
- VernacularTitle:骨骼肌减少症与直肠癌术后吻合口瘘的相关性研究
- Author:
Mengxin CHEN
1
;
Shuxian LI
;
Wenjin DONG
;
Tianqi LIU
;
Can WANG
;
Xingyi LIU
;
Sha LIAO
;
Fengshu ZHAO
;
Rui ZHANG
;
Wenhong WANG
Author Information
1. 天津中医药大学医学技术学院,天津 301617;天津市人民医院(南开大学第一附属医院)放射科,天津 300121
- Publication Type:Journal Article
- Keywords:
rectal cancer;
computed tomography;
anastomotic leakage;
sarcopenia
- From:
Journal of Practical Radiology
2025;41(9):1498-1502
- CountryChina
- Language:Chinese
-
Abstract:
Objective To quantitatively assess the correlation between the skeletal muscle index(SMI)of patients and the occur-rence of anastomotic leakage(AL)in rectal cancer patients after surgery,and to analyze the risk factors for AL in rectal cancer patients and the influencing factors of sarcopenia.Methods The clinical,pathological,and related imaging data of 362 patients who under-went radical surgery for rectal cancer were retrospectively analyzed.All patients underwent pelvic MRI and abdominal CT scans(plain/enhanced)within one month before surgery,and the third lumbar vertebra skeletal muscle area(L3-SMA)was measured from the images.All patients were divided into AL group(56 cases)and control group(306 cases)based on the presence or absence of postoperative complications.The differences in clinical characteristics and imaging parameters between the two groups were analyzed.A logistic risk prediction model was established.Results Significant differences were observed between the two groups in sarcopenia,type of surgery,surgical approach,serum albumin level,operation duration,stoma type,and extramural vascular invasion(EMVI)(P＜0.05).These factors were incorporated in a multivariate logistic regression analysis model,the area under the curve(AUC)of receiver operating characteristic(ROC)curve of the model was 0.810[95％confidence interval(CI)0.743-0.876,P＜0.001],with a sensitivity of 0.865 and specificity of 0.669.Conclusion Sar-copenia is a significant risk factor for AL after rectal cancer surgery.It enhances the predictive efficacy for postoperative AL and serves as a basis for identifying high-risk populations for AL in clinical practice.
