Interaction between rs12437118 Polymorphism of ERRB Gene and Serum 25(OH)D Level on Multi-drug Resistance of Tuberculosis in Patients with Pulmonary Tuberculosis
10.3969/j.issn.1671-7414.2025.06.011
- VernacularTitle:肺结核患者ERRB基因rs12437118多态性与血清25(OH)D水平的交互作用对结核耐多药的影响研究
- Author:
Xueyi WANG
1
;
Tingting ZHOU
1
;
Wenfeng WU
1
Author Information
1. 新疆维吾尔自治区人民医院,乌鲁木齐 830001
- Publication Type:Journal Article
- Keywords:
estrogen-related receptor beta;
polymorphism;
25-hydroxyvitamin D;
tuberculosis;
multidrug resistance tuberculosis
- From:
Journal of Modern Laboratory Medicine
2025;40(6):56-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the interaction between estrogen-related receptor β(ERRB)gene rs12437118 polymorphism and serum 25-hydroxyvitamin D[25(OH)D]level on tuberculosis multidrug resistance in patients with pulmonary tuberculosis.Methods A total of 104 multidrug resistant tuberculosis(MDR-TB)patients admitted to People's Hospital of Xinjiang Uygur Autonomous Re-gion from January 2018 to December 2023 were selected as the MDR-resistant group,and 102 non-MDR-resistant tuberculosis pa-tients treated of People's Hospital in Xinjiang Uygur Autonomous Region during the same period were selected as the control group.The gene frequency was compared between the two groups.Multivariate Logistic regression was used to analyze the influencing factors of MDR.Multiple linear regression was used to analyze the association of ERRB gene rs12437118 polymorphism with mul-tidrug resistance and 25(OH)D.The interaction between ERRB gene rs12437118 genotype and 25(OH)D on multidrug resistance was analyzed by unconditional Logistic regression model.Results The frequencies of GG(50.96%)and AA(13.46%)genes in MDR group were significantly higher than those in control group(37.25%,9.80%),and the difference was statistically significant(χ2=6.296,P<0.05).There was no significant difference in the frequencies of G and A alleles between the two groups(χ2=1.163,P>0.05).Mul-tivariate Logistic regression analysis showed that age,place of residence,treatment history,smoking history,empty number,regular medication,occupation,rs12437118 G allele and 25(OH)D were all independent influencing factors on multidrug resistance(Wald χ2=0.873～3.152,all P<0.05).Multiple linear regression analysis showed that rs12437118 was significantly associated with MDR risk in allele model,additive model,dominant model and recessive model(all P<0.05).The results of interaction analysis showed that the effects of rs12437118 genotype G allele and 25(OH)D on multidrug resistance were interactive in additive and multiplica-tive models.Conclusion The effects of rs12437118 genotype G allele of ERRB gene and 25(OH)D on multidrug resistance in pulmonary tuberculosis patients interacted in additive model and multiplicative model,and the risk of multidrug resistance is higher when both exist together.
