Progress in the study of the effect and mechanism of different mesenchymal stem cells and their exosomes in the treatment of premature ovarian insufficiency

VernacularTitle:不同来源的间充质干细胞及其外泌体治疗早发性卵巢功能不全的作用及机制研究进展
Author: Xinyang ZHAO ¹ ; Jichun TAN ¹
Author Information

1. 中国医科大学附属盛京医院妇产科生殖医学中心/辽宁省生殖障碍疾病与生育力重塑重点实验室，沈阳　110022
Publication Type:Journal Article
Keywords: Mesenchymal stem cell; Premature ovarian insufficiency; Exosome; Granulosa cell
From: Chinese Journal of Reproduction and Contraception 2021;41(7):661-667
CountryChina
Language:Chinese
Abstract: Premature ovarian insufficiency (POI) is an endocrine disease that seriously affects reproductive health and life quality of women of childbearing age. At present, there is no effective treatment to restore ovarian function. In recent years, many studies have shown that different sources of mesenchymal stem cells (MSC), cytokines and exosomes secreted by MSC can restore the ovarian function and fertility of POI patients by improving the microenvironment of ovarian tissue, immunomodulation, promoting follicular development, inhibiting granulosa cell apoptosis and so on. This article reviewed the current status of the treatment of POI, the possibility assessment and mechanism of different MSC and their exosomes.