A case report of cryopreserved ovarian tissue retransplantation in endometrial cancer
10.3760/cma.j.cn101441-20200715-00396
- VernacularTitle:子宫内膜癌卵巢组织冻存自体移植1例报道
- Author:
Xiangyan RUAN
1
;
Jiaojiao CHENG
;
Juan DU
;
Yanglu LI
;
Fengyu JIN
;
Dan LU
;
Rong ZHOU
;
Yinmei DAI
;
Qi ZHOU
;
Matthias KORELL
;
Husheng WANG
;
Muqing GU
;
Mueck Alfred O.
Author Information
1. 首都医科大学附属北京妇产医院 100026
- Publication Type:Journal Article
- Keywords:
Ovarian tissue cryopreservation;
Ovarian tissue transplantation;
Endometrial cancer;
Ovarian ovulation;
Ovarian function
- From:
Chinese Journal of Reproduction and Contraception
2021;41(7):644-649
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To preserve fertility and endocrine function of an endometrial carcinoma patient by ovarian tissue cryopreservation and transplantation.Methods:Part of the ovary was harvested and cryopreserved when surgery for a 33-year-old woman who was diagnosed with endometrial carcinoma. After the cancer reached remission, the patient underwent cryopreserved ovarian tissue transplantation. The endocrine hormone, follicle growth, and menopausal syndromes were detected.Results:One month after the surgery of transplantation, the modified Kupperman scores decreased from 12 to 2, and the menopausal syndrome disappeared. Two months after the operation of transplantation, the concentration of follicle-stimulating hormone (FSH) decreased to 21.78 IU/L, the level of estradiol increased from 13.76 ng/L to 65.55 ng/L, and follicle growth was observed by ultrasound. Four months after the surgery of transplantation, the level of FSH decreased to 6.26 IU/L, the level of estradiol increased to 112.22 ng/L. Nine months after the operation of transplantation, the level of estradiol was 118.14 ng/L, the level of progesterone increased to 8.96 μg/L, and two corpus luteum after ovulation were detected by ultrasound.Conclusion:Two months after the surgery of transplantation, the ovarian function has returned to normal, which demonstrated the success of transplantation of frozen-thawed ovarian tissue.
