Resting brain function study of executive function changes in patients with type 2 diabetes mellitus
10.3969/j.issn.1002-1671.2025.09.001
- VernacularTitle:2型糖尿病患者执行功能改变的静息态脑功能研究
- Author:
Yanyan CUI
1
;
Ying YU
;
Bo HU
;
Sining LI
;
Xinyu CAO
;
Pan DAI
;
Minhua NI
;
Xiaoyan BAI
;
Yao TONG
;
Lijuan DU
;
Linfeng YAN
;
Guangbin CUI
Author Information
1. 陕西中医药大学医学技术学院,陕西 咸阳 712046;空军军医大学唐都医院放射科,陕西 西安 710038
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
executive function;
functional magnetic resonance imaging;
frontoparietal control network;
salience network
- From:
Journal of Practical Radiology
2025;41(9):1427-1431
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes in neural activity in patients with type 2 diabetes mellitus(T2DM)and their corre-lation with executive function,and to analyze the neural mechanisms underlying the decline in executive function in T2DM patients.Methods Thirty-one T2DM patients(T2DM group)and thirty-two healthy controls(HC)(HC group)matched for body mass index(BMI)underwent resting-state functional magnetic resonance imaging(rs-fMRI)scans and N-back task tests were included.Differ-ences in the amplitude of low-frequency fluctuation(ALFF),regional homogeneity(ReHo),and seed-based functional connectivity(FC)between the two groups were compared,and partial correlation analyses were performed between the difference results and N-back task performance.Results The T2DM group showed prolonged reaction time(RT)in the 1-back and 2-back tasks.T2DM patients exhibited increased ALFF in the bilateral caudate nucleus,left medial superior frontal gyrus,and right postcentral gyrus,as well as elevated ReHo in the right putamen.FC analysis revealed significant alterations in FC between the caudate nucleus,putamen,and multiple brain regions in T2DM patients,with some of these FC changes significantly correlated with RT and accuracy(ACC)in the N-back task.Conclusion The decline in executive function in T2DM patients may be associated with abnormal neural activity in brain regions such as the striatum,salience network,and frontoparietal control network.FC further decreases under increased cognitive load.These findings provide evidence for the study of the neural mechanisms of executive function impairment in T2DM patients.
