Advances in molecular mechanisms of the association between hypoxia inducible factor-1α and endometrial receptivity
10.3760/cma.j.cn101441-20200706-00380
- VernacularTitle:低氧诱导因子-1α与子宫内膜容受性相关性及其分子机制研究进展
- Author:
Lixia LIANG
1
;
Yanling LIU
1
;
Xiuping ZHANG
1
;
Zhiping ZHANG
1
;
Xueqing WU
1
Author Information
1. 山西省妇幼保健院生殖医学中心，太原 030013
- Publication Type:Journal Article
- Keywords:
Hypoxia inducible factor-1α;
Vascular endothelial growth factor;
Glucose metabolism;
Autophagy;
Endometrial receptivity
- From:
Chinese Journal of Reproduction and Contraception
2021;41(5):392-397
- CountryChina
- Language:Chinese
-
Abstract:
It is well known that not only the embryo quality but also the endometrial receptivity leads to the unsuccessful embryo implantation, which is the cause of recurrent spontaneous abortion (RSA) and recurrent implantation failure (RIF). The establishment of endometrial receptivity is a complex physiological process involving multiple cytokines and chemical moleculars, and the mechanisms are not yet clear. During embryo implantation, the endometrium is in a state of physiological hypoxia and low energy supply. At this time, the intracellular hypoxia response mechanism is activated. Hypoxia inducible factor-1α (HIF-1α) participates in endometrial decidualization by regulating various molecular mechanisms, such as angiogenesis, glucose metabolism and autophagy, thereby enabling implantation to proceed smoothly. This article describes the expression of HIF-1α in the endometrium and its possible molecular mechanism during the establishment of endometrial receptivity.
