Molecular Mechanisms of Angiogenesis in Mg-Based Biodegradable Bone Implants
10.13241/j.cnki.pmb.2025.16.018
- VernacularTitle:镁基可降解骨植入材料促血管新生分子机制研究前沿
- Author:
Jun-jie HUANG
1
;
Jia-long WU
;
Di LIU
;
Peng GAO
Author Information
1. 湖南师范大学附属第一医院(湖南省人民医院) 湖南长沙 410000
- Publication Type:Journal Article
- Keywords:
Bone implant materials;
Magnesium metal;
Angiogenic effect;
Angiogenic mechanism
- From:
Progress in Modern Biomedicine
2025;25(16):2705-2714
- CountryChina
- Language:Chinese
-
Abstract:
Magnesium(Mg)-based bone implants have emerged as a promising candidate in bone regeneration due to their elastic modulus matching natural bone,favorable biodegradability,and biocompatibility.The degradation-derived magnesium ions(Mg2+)promote angiogenesis through multifaceted molecular mechanisms,thereby accelerating bone healing.This review systematically elucidates key pathways by which Mg2+regulates vascularization:① Activation of the CGRP-FAK-VEGF signaling axis via dorsal root ganglia-mediated neurovascular coupling;② Stabilization of HIF-1α through inhibiting VHL-mediated ubiquitination degradation and activating MagT1/TRPM7 ion channels,thereby enhancing VEGF transcription;③ Modulation of Notch signaling to drive vascular endothelial differentiation of bone marrow mesenchymal stem cells(BMSCs);④The activation of PI3K/AKT signaling pathway enhances endothelial nitric oxide synthase(eNOS)activity,leading to increased nitric oxide(NO)production which subsequently promotes endothelial cell proliferation and migration;⑤Immunomodulatory effects via macrophage M2 polarization and subsequent secretion of angiogenic factors;⑥stimulation of PDGF-BB secretion from MC3T3-E1 pre-osteoblasts.Notably,Mg2+exhibits concentration-dependent pro-angiogenic effects(optimal range:1-10 mM)and specifically enhances type H vessel formation,which critically couples angiogenesis with osteogenesis to boost bone regeneration efficiency.
