Thin endometrium is an independent risk factor for low birth weight of singleton in fresh embryo transfer
10.3760/cma.j.cn101441-20200523-00303
- VernacularTitle:薄型子宫内膜是新鲜胚胎移植单胎子代低出生体质量的危险因素
- Author:
Junwei ZHANG
1
;
Mingze DU
1
;
Yichun GUAN
1
;
Xingling WANG
1
;
Zhen LI
1
;
Lijun SUN
1
Author Information
1. 郑州大学第三附属医院生殖医学科，郑州 450052
- Publication Type:Journal Article
- Keywords:
Embryo transfer;
Low birth weight;
Thin endometrium
- From:
Chinese Journal of Reproduction and Contraception
2022;42(1):24-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of thin endometrial thickness (EMT) on the low birth weight (LBW) of singleton in fresh embryo transfer cycle.Methods:It was a retrospective cohort study. The data of singleton deliveries achieved after fresh cleavage embryo transfer in the Reproductive Center of the Third Affiliated Hospital of Zhengzhou University from January 2015 to February 2019 were included. A total of 2247 cycles were included and were divided into three groups depending on the EMT: group A≤7.5 mm, group B 7.6-12.0 mm and group C>12.0 mm. The major outcome measure was LBW. Binary logistic regression was performed to correct for confounding factors.Results:Singleton birthweight was lower in group A [3000(2525, 3350) g] compared with group B and group C [3350(3050, 3650) g, 3400(3100, 3690) g, all P<0.001]. The incidence of LBW in group A [24.7% (20/81)] was significantly higher than that in groups B and C [4.0% (57/1414), 5.3% (40/752), all P<0.001], while there was no statistical difference between groups B and C ( P>0.05). Body mass index ( P=0.029), estrogen level on the human chorionic gonadotropin (hCG) trigger day ( P=0.027), EMT ( P<0.001), gestational age ( P<0.001) and the gender of the newborn ( P<0.001) were independent factors of LBW. The incidence of LBW increased when the body mass index and gestational age were smaller and estrogen level on the hCG trigger day was ≥4000 ng/L. Taking group B as control group, the incidence of LBW in group A increased significantly and was an independent risk factor for LBW (a OR=4.39, 95% CI=1.85-10.46, P<0.001), while the incidence of LBW in group C had no significant difference (a OR=0.90, 95% CI=0.51-1.59, P=0.723). Conclusion:In the fresh cleavage stage embryo transfer cycle, singleton birth weight was lower in thin EMT group. And thin EMT was an independent risk factor for LBW of singleton delivery.
