Role and mechanism of m7G methylation modification in tumor drug resistance
10.3969/j.issn.1671-7856.2025.08.012
- VernacularTitle:m7G修饰在肿瘤耐药中的作用及机制
- Author:
Lu LU
1
;
Huiting YANG
;
Boyang LIU
;
Qian LI
;
Bitang HUANG
;
Shenglan GAO
;
Chunlong YANG
;
Qingjun PAN
Author Information
1. 广东医科大学附属医院检验医学中心,广东湛江 524001
- Publication Type:Journal Article
- Keywords:
methylation modification;
m7G;
tumor;
drug resistance
- From:
Chinese Journal of Comparative Medicine
2025;35(8):120-130
- CountryChina
- Language:Chinese
-
Abstract:
N7-methylguanosine(m7G)modification occurs at the 5'cap of mRNA in eukaryotes,and is also found at specific sites on tRNA and rRNA,showing wide conservation across various biological organisms.Aberrant m7G modification is involved in the dysregulation of gene expression and serves as a biomarker for multiple cancers,with significant potential for applications in tumor diagnosis and therapy.This review summarizes the biological functions and regulatory mechanisms of m7G modification,and outlines its potential clinical applications.It also highlights the oncogenic roles of aberrant m7G modification and its association with prognosis,providing a detailed discussion of the role and molecular mechanisms of abnormal m7G modification in regulating drug resistance in various cancers.
