Research Progress on Extraction and Isolation,Characterization and Identification of Wear Debris for Artificial Joints
10.16156/j.1004-7220.2025.05.033
- VernacularTitle:人工关节假体磨屑提取分离、表征和识别的研究进展
- Author:
Shu YANG
1
;
Ruijuan LIU
;
Jiazhen ZHANG
;
Bao ZHAI
;
Zikai HUA
;
Jinju DING
;
Bin LIU
Author Information
1. 国家药品监督管理局医疗器械技术审评检查大湾区分中心,广东 深圳 518000
- Publication Type:Journal Article
- Keywords:
artificial joint;
wear debris;
isolation;
characterization analysis;
intelligent recognition
- From:
Journal of Medical Biomechanics
2025;40(5):1333-1342
- CountryChina
- Language:Chinese
-
Abstract:
The wear debris generated during artificial joint prosthesis service can react with bone tissues to form osteolysis,seriously affecting the life-time of artificial joint prostheses.This paper reviews,summarizes,and analyzes domestic and international research literature on the extraction,characterization,and identification of wear debris from different artificial joint materials,aiming to provide references and feasible ideas for the future construction of a systematic and hierarchical research system for artificial joint wear debris.The main findings are as follows:strong alkali protein degradation test,strong acid protein degradation test,and protease protein degradation test are the commonly used method for extracting artificial joint wear debris,and researchers have clarified the protein degradation mechanisms of these three debris extraction methods.The characterization of wear debris in-vitro and in-vivo is mostly for hip and knee joints,with a small amount involving cervical spine and ankle joints.Studies have shown that the size,quantity,shape,and volume of wear particles are influenced by factors such as joint type,contact area,material selection,and implantation time.Both domestic and international studies have conducted characterization research on wear debris after in-vitro simulation testing,but there is still a lack of wear debris characterization analysis of clinical retrievals in China.Currently,most research is on the recognition of wear debris in the traditional mechanical field,but research on the intelligent recognition of artificial joint wear debris is relatively few,indicating that there is a certain lag in the application of computer technology in the field of artificial joint wear debris recognition.
