Association of Residual Cholesterol and Type 2 Diabetes and its Mechanism of Action
10.13241/j.cnki.pmb.2025.16.019
- VernacularTitle:残余胆固醇与2型糖尿病血管病变的关联性及其作用机制研究进展
- Author:
Li-xian ZHAO
1
;
Jing ZHOU
;
Yang WANG
;
Juan LI
;
Xiao-hai LI
Author Information
1. 河北化工医药职业技术学院 河北石家庄 050026
- Publication Type:Journal Article
- Keywords:
Residual cholesterol;
Type 2 diabetes mellitus;
Vascular lesions;
Mechanism of action
- From:
Progress in Modern Biomedicine
2025;25(16):2715-2720
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes(T2DM)was a chronic metabolic disease,vascular lesions was one of the common complications of T2DM,including microvascular and macrovascular lesions,which seriously threatens the health of patients and increases the risk of disability and death.Dyslipidemia was one of the pathogenesis of type 2 diabetes,the disorder of lipid metabolism was also closely related to various acute and chronic complications of diabetes,the cholesterol in the lipoproteins rich in triglycerides(TG)was known as residual cholesterol.Existing studies have shown that,residual cholesterol was closely related to the occurrence and development of vascular lesions in T2DM.Residual cholesterol may be involved in T2DM vascular lesions through mediating inflammatory response,participating in oxidative stress,lipid metabolism disorder and direct damage to vascular endothelial function.This study reviewed the association between residual cholesterol and T2DM vascular lesions and its mechanism of action in T2DM vascular lesions,aiming to provide solid theoretical support for the formulation of prevention and treatment strategies for T2DM vascular lesions.
