Observation of Ultrasound Changes and Clinical Efficacy of Ultrasound-Guided Compound Betamethasone Injection in the Treatment of First Metatarsophalangeal Joint in Acute Gouty Arthritis
10.13241/j.cnki.pmb.2025.16.005
- VernacularTitle:超声引导下复方倍他米松注射治疗急性痛风性第一跖趾关节关节炎的超声改变及临床疗效观察
- Author:
Hui ZHOU
1
;
Bin ZHANG
;
Wen-juan GAO
;
Yu-ling ZHANG
;
Jing-jing MA
;
Ming LI
Author Information
1. 潍坊市人民医院风湿免疫科 山东潍坊 261041
- Publication Type:Journal Article
- Keywords:
Acute gouty arthritis;
First metatarsophalangeal joint;
Ultrasound-guided;
Compound betamethasone injection
- From:
Progress in Modern Biomedicine
2025;25(16):2608-2614
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the ultrasound changes,clinical efficacy and safety of ultrasound-guided compound betamethasone injection in the treatment of first metatarsophalangeal joint(MTP1)in acute gouty arthritis.Methods:This study was a prospective randomized controlled trial,71 patients diagnosed with MTP1 in acute gouty arthritis in Weifang People's Hospital from June 2022 to June 2024 were selected,they were divided into puncture treatment group of 36 cases and oral medication group of 35 cases according to the random number table method.The puncture treatment group was treated with ultrasound-guided compound betamethasone injection,and the oral medication group was treated with etocoxib combined with colchicine.Visual Analogue Scale(VAS),inflammatory indicators[erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)],and semi-quantitative scores of musculoskeletal ultrasound of the two groups were compared,and the medication safety of the two groups was observed.Result:1,3 and 7 days after treatment,VAS score in the puncture treatment group decreased significantly compared with that in the oral medication group(P＜0.05).7 days after treatment,ESR and CRP in the puncture treatment group decreased more significantly,and semi-quantitative scores of musculoskeletal ultrasound showed that the improvement of joint effusion,synovial hyperplasia and blood flow signal was better than that in the oral medication group(P＜0.05).All 36 cases of puncture were successful at the first attempt without complications.Conclusion:Ultrasound-guided compound betamethasone injection in the treatment of MTP1 in acute gouty arthritis has a high success rate,it can rapidly reduce inflammation,relieve pain,restore joint function,and is safe to operate,it can be used as an effective treatment option.
