Abnormal Resting-State Percent Amplitude of Fluctuation and Functional Connectivity in Primary Insomnia Patients
10.3969/j.issn.1005-5185.2025.08.003
- VernacularTitle:原发性失眠患者大脑静息态低频振荡振幅百分比和功能连接变化
- Author:
Bingqing DONG
1
;
Yujie JIANG
;
Juntao CAO
;
Jianchun TU
;
Hui ZHANG
Author Information
1. 昆山市中医医院放射科,江苏 昆山 215300
- Publication Type:Journal Article
- Keywords:
Primary insomnia;
Functional magnetic resonance imaging;
Percent amplitude of fluctuation;
Functional connectivity
- From:
Chinese Journal of Medical Imaging
2025;33(8):811-815,821
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the changes of brain function and network in primary insomnia(PI)patients using the percent amplitude of fluctuation(perAF)combined with functional connectivity(FC).Materials and Methods A total of 51 PI patients and 45 normal controls underwent resting functional magnetic resonance scans in Kunshan Traditional Chinese Medicine Hospital from November 2019 to December 2022,then the perAF value and FC in brain regions of different perAF value between the two groups was analyzed.Pearson correlation analysis was used to investigate the relationships between the altered perAF values and insomnia years,Pittsburgh sleep quality index and Montreal cognitive assessment.Results Compared with healthy group,PI patients had increased perAF values in the left prefrontal lobe(-42 9 45)and decreased perAF values in the right parahippocampal gyrus(27-12-27)[Gaussian random field(GRF)correction,voxel-wise P<0.001,cluster-level P<0.05].FC analysis showed that the right parahippocampal gyrus of PI patients exhibited significantly increased FC with the left middle temporal gyrus,inferior temporal gyrus(-57-15-33)and the left middle occipital gyrus(-30-78 27)(GRF corrected,voxel-wise P<0.001,cluster-level P<0.05).It was noteworthy that the perAF values of the right parahippocampal gyrus were positively correlated with Montreal cognitive assessment of PI patients(r=0.428,P=0.002).Conclusion Specific brain areas in PI patients may exhibit aberrant neuronal activity,mainly manifested as decreased perAF value in the right parahippocampal gyrus,which was increased FC with the left middle temporal gyrus,inferior temporal gyrus and the left middle occipital gyrus.These discoveries may be the core of the mechanism of impaired brain function in PI patients.
