Functional Connectivity of Lower Limb Sensorimotor Cortex in Type 2 Diabetic Peripheral Neuropathy via Resting-State fMRI
10.3969/j.issn.1005-5185.2025.08.002
- VernacularTitle:2型糖尿病周围神经病变患者下肢感觉运动皮层功能连接的静息态fMRI研究
- Author:
Yitong GUAN
1
;
Wanting LIU
;
Peichun PAN
;
Jing LI
;
Chenyu ZHANG
;
Yang HUANG
;
Dongsheng ZHANG
;
Xiaoling ZHANG
Author Information
1. 西安医学院研究生处,陕西 西安 710021
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Peripheral nervous system diseases;
Functional magnetic resonance imaging;
Sensorimotor cortex;
Functional connectivity
- From:
Chinese Journal of Medical Imaging
2025;33(8):805-810
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the functional connectivity(FC)pattern between the bilateral lower limb sensorimotor cortex(LSM)and the whole brain in type 2 diabetic peripheral neuropathy(DPN).Materials and Methods A total of 44 DPN patients and 43 healthy controls admitted to Shaanxi Provincial People's Hospital from February 2021 to December 2022 were enrolled prospectively and underwent neuropsychological assessment and resting-state fMRI scans.Using bilateral LSM as the regions of interest,the differences of bilateral LSM and whole brain FC between DPN patients and healthy controls were compared.FC in different brain areas were extracted and correlated with clinical/neuropsychological scores.Results Compared with healthy controls,DPN patients had reduced FC of the LSM with the right cerebellar lobule Ⅵ,the right lateral occipitotemporal cortex,the bilateral rostral prefrontal cortex and the bilateral anterior cingulate gyrus.The FC between LSM and right cerebellar Ⅵ in DPN patients were significantly negatively correlated with fasting blood glucose(r=-0.490,P=0.001).The FC between LSM and bilateral anterior cingulate gyrus in DPN patients were significantly positively correlated with Montreal cognitive assessment scores(r=0.479,P=0.001).Conclusion Abnormal FC between LSM and multiple brain regions,suggesting that DPN may have extensive effects on brain regions that maintain motion and motor control function in type 2 diabetes mellitus patients.
