Analysis of new and serious adverse drug reactions from 2020 to 2024
10.3969/j.issn.1671-332X.2025.10.012
- VernacularTitle:2020-2024年新的和严重药品不良反应分析
- Author:
Xiaowen ZHOU
1
;
Meichen ZHOU
1
;
Wanmei WU
1
;
Honglan ZHONG
1
Author Information
1. 广州市胸科医院 广东 广州 510095
- Publication Type:Journal Article
- Keywords:
New adverse drug reaction;
Serious adverse drug reaction;
Rational drug use;
Anti-tuberculosis drugs;
An-tineoplastic drugs
- From:
Modern Hospital
2025;25(10):1527-1531
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics of new and serious adverse drug reactions(ADRs)and provide a basis for safe medication use.Methods A retrospective analysis was conducted on 279 cases of new and serious ADRs reported at Guangzhou Chest Hospital from 2020 to 2024.Data on the type of ADR report,organs/systems involved,patient age and gender,categories of drugs involved,and dosage forms were collected for characteristic and pattern analysis.Results The majority of cases were serious ADRs(63.8％),with a higher proportion in males(57.3％,male-to-female ratio=1.34∶1).Patients aged 45 years and above accounted for 63.1％of cases.The ADRs involved 96 drugs from 12 categories,with anti-infec-tive drugs accounting for 75.0％.Oral administration(65.1％)and intravenous infusion(32.6％)were the main routes of ad-ministration.Digestive system damage was the most common(39.1％),followed by skin and appendage damage(12.3％),he-matologic system damage(10.5％),and nervous system damage(9.6％).Conclusion The occurrence of ADRs is associated with multiple factors such as age and route of administration.There is a need to strengthen multidisciplinary collaboration,en-hance medication monitoring and ADR surveillance in clinical practice to ensure medication safety.
