Characterization of a Physiological Mock Circulation System Based on Capillary-Bundle Resistance Element
10.16156/j.1004-7220.2025.05.023
- VernacularTitle:基于毛细管束阻抗元件的仿生理脉动循环台参数定量化研究
- Author:
Dengji LIU
1
;
Xinke CHEN
1
;
Lisha HAN
1
;
Zhen CAO
1
;
Qingzhuo CHI
1
;
Kai YIN
1
;
Ying HE
1
Author Information
1. 大连理工大学能源与动力学院,海洋能源利用与节能教育部重点实验室,辽宁大连 116024
- Publication Type:Journal Article
- Keywords:
pulsatile mock circulation loop;
capillary-bundle resistance;
pressure waveform;
lumped parameter model;
pulsatile piston pump
- From:
Journal of Medical Biomechanics
2025;40(5):1256-1264
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the feasibility of parallel capillary bundle arrays for physiomimetic impedance modeling and establish a parametric quantification framework,thereby providing a customizable impedance characterization methodology for diverse in-vitro mock circulation researches.Methods Based on the parallel flow resistance and Poiseuille equation,a tube resistance element with multiple parallel-aligned capillary glass tubes was designed and fabricated.The resistance values of the capillary-bundle and a ball valve were measured through constant flow experiments analogous to electrical resistance measurement method.Moreover,a simple lumped-parameter mock circulation loop was constructed and the pressure and flow rate for each node of the loop were measured under different input flow waveforms.An 0D-Windkessel model corresponding to the experiment was developed.The impedance and compliance were adjusted to match the simulated and experimental pressure and flow waveforms.The accuracy of the capillary bundle impedance in pulsatile experiments was verified by using the computational resistance values.Results The constant-flow impedance calibration experiments revealed that the capillary bundle impedance remained unaffected by flow rate variations over a wide flow range.When the capillary bundle impedance was integrated into the pulsatile circulatory system and the same impedance value obtained from the constant-flow calibration was applied in the computational model,the resulting pressure and flow waveforms showed good agreement with those measured in the pulsatile experiments.However,when the ball valves with nominally identical impedance values were inserted in the pulsatile system,the calculated impedance exhibited a two-fold difference,and significant discrepancies were observed between the simulated and experimental terminal flow waveforms.Conclusions The capillary bundle impedance maintains a constant value regardless of flow rate variations.Once the calibrated resistance value is determined through constant flow experiments,it can be directly applied to pulsatile systems.This approach can provide quantitative pulsatile flow conditions for testing various medical devices.
