Hemodynamic Comparison of Different Cannulation Methods in Extracorporeal Membrane Oxygenation System
10.16156/j.1004-7220.2025.05.020
- VernacularTitle:体外膜肺氧合系统不同插管方式的血流动力学对比
- Author:
Yajing ZHANG
1
;
Dongsheng ZHANG
;
Lu HAN
Author Information
1. 上海大学力学与工程科学学院,上海应用数学与力学研究所,上海市能源工程力学重点实验室,上海 200444
- Publication Type:Journal Article
- Keywords:
veno-arterial extracorporeal membrane oxygenation;
lumped parameter model;
cardiovascular circulatory system;
left ventricular unloading;
hemodynamics
- From:
Journal of Medical Biomechanics
2025;40(5):1230-1238
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effects and differences of two veno-arterial extracorporeal membrane oxygenation(VA-ECMO)cannulation methods and subsequent left ventricular unloading on cardiac function and hemodynamics.Methods The lumped parameter model(LPM)of VA-ECMO integrated with the cardiovascular system in the MATLAB/Simulink environment was extended to simulate and analyze the changes in ventricular function and blood flow in the heart failure patient model under central VA-ECMO or peripheral VA-ECMO support.The effects of using arterial vasodilators or a left atrial drainage cannula on left ventricular function under central VA-ECMO support at a pump flow rate of 3 L/min were compared.Results Under central VA-ECMO or peripheral VA-ECMO support,left ventricular pressure and volume increased,and stroke volume and ventricular work decreased.Both arterial vasodilators and the left atrial drainage cannula could reduce left ventricular pressure and volume.Arterial vasodilators additionally increased stroke volume and improved left ventricular ejection fraction from 11.6％to 19.5％.Conclusions Both VA-ECMO cannulation methods provide effective circulatory support in the heart failure patient model,with similar effects on ventricular function.Under central VA-ECMO support,arterial vasodilators can improve left ventricular function more effectively than the left atrial drainage cannula.
