Function and potential mechanism of CD55 in endometrium
10.3760/cma.j.cn101441-20200615-00344
- VernacularTitle:CD55对子宫内膜的影响及可能机制
- Author:
Zhijing TANG
1
;
Wei ZHANG
1
Author Information
1. 复旦大学附属妇产科医院生殖内分泌科，上海 200011
- Publication Type:Journal Article
- Keywords:
CD55;
Endometrium;
Gestation;
Biological behavior
- From:
Chinese Journal of Reproduction and Contraception
2022;42(1):104-108
- CountryChina
- Language:Chinese
-
Abstract:
The establishment of pregnancy depends on the normal function of endometrium. CD55 is up-regulated in the secretory endometrium and reaches the peak during the window of implantation, while abnormal expression of CD55 is associated with recurrent abortion, repeated implantation failure, endometriosis, endometrial cancer and other endometria-related diseases. Besides inhibiting the complement-dependent cytotoxicity as a complement regulatory protein, CD55 in endometrium also plays a role in regulating cell cycle, promoting cell proliferation, inhibiting apoptosis, and promoting cell invasion, migration and adhesion. CD55 can also bind its ligand CD97 as inhibitory signals of T cells and natural killer (NK) cells and participate in promoting cell invasion and migration in non-immune cells. This review summarizes the role of CD55 in endometrium and its potential regulatory mechanism, providing more evidence for exploring the function of CD55 in endometrial receptivity establishment and embryo implantation.
