Effect of endometrial thickness on birth weight in frozen-thawed embryo transfer cycles
10.3760/cma.j.cn101441-20200120-00047
- VernacularTitle:子宫内膜厚度对冻融胚胎移植胎儿出生体质量的影响
- Author:
Lijun ZHANG
1
;
Yayi GAO
1
;
Mengmeng TIAN
1
;
Xingling WANG
1
Author Information
1. 郑州大学第三附属医院生殖医学中心 450052
- Publication Type:Journal Article
- Keywords:
Endometrial thickness;
Frozen-thawed embryo transfer;
Birth weight
- From:
Chinese Journal of Reproduction and Contraception
2021;41(1):42-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of endometrial thickness on birth weight in frozen-thawed embryo transfer cycles.Methods:A retrospective cohort analysis of 1622 single-birth live birth cycles of frozen-thawed embryo transfer at the Reproductive Center of the Third Affiliated Hospital of Zhengzhou University from June 2016 to December 2018 was performed. According to the endometrial thickness on the day of transplantation, the patients were divided into four groups, group A: endometrial thickness ≤8 mm; group B: endometrial thickness 8-10 mm; group C: endometrial thickness 10-12 mm; group D: endometrial thickness ≥12 mm. The general and clinical data of patients in each group were compared. Group A was used as the reference group to control confounding factors and the low birth weight (LBW) and very low birth weight (VLBW), term LBW, small for gestational age (SGA), preterm birth odds ratio ( OR), and 95% confidence interval (95% CI) were calculated, and multiple linear regression was used to analyze the impact factors related to the birth weight of the fetus. Results:The fetal birth weights of the four groups were (3 350.15±568.17) g, (3 318.84±523.43) g, (3 459.93±483.73) g, (3 482.27±495.30) g in order ( P>0.05). After adjusting for confounding factors through multivariate logistic regression analysis, the risk of preterm birth in group A was greater than that in group C ( OR=0.527,95% CI=0.287-0.968, P=0.039). Endometrial thickness did not affect the incidence of LBW, VLBW, term LBW, and SGA ( P>0.05). Further, multiple linear regression analyses indicated that body mass index, embryo transfer stage, gestation week, and newborn gender all affected the fetal birth weight ( P<0.001, P=0.003, P<0.001, P<0.001). Conclusion:In the frozen-thawed embryo transfer cycle, the women with endometrial thickness ≤8 mm on the day of transplantation are more likely to have premature birth than women with endometrial thickness of 10-12 mm, but endometrial thickness does not affect the fetal birth weight.
