Effects of perinatal maternal lower genital tract ureaplasma urealyticum colonization on neurodevelop-ment during the fidgety movements period of infants
10.3969/j.issn.1001-1242.2025.11.013
- VernacularTitle:围产期母体下生殖道解脲脲原体定植对婴儿不安运动阶段神经发育的影响
- Author:
Hainan WANG
1
;
Ming ZHANG
;
Chun SU
Author Information
1. 徐州医科大学附属徐州康复医院,江苏省 徐州市,221010
- Publication Type:Journal Article
- Keywords:
perinatal period;
ureaplasma urealyticum;
lower genital tract;
fidget movements;
neurodevelopment
- From:
Chinese Journal of Rehabilitation Medicine
2025;40(11):1694-1700
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Investigating the effect of perinatal maternal lower genital tract ureaplasma urealyticum(UU)colo-nization on neurodevelopment in infants at the fidget movements phase(FMs).Method:This study is a retrospective cohort with moms who were conducted UU testing in the prenatal low-er genital tract,and infants who underwent general movements assessment(GMs)and cranial magnetic reso-nance imaging(MRI)throughout the FMs phase.In addition,the last GMs was served as the cohort endpoint.71 cases of perinatal maternal lower vaginal tract UU colonization and 69 cases of UU non-colonization were included in this study.The relationship between subgroups and the relationship between UU-DNA copy number and neurodevelopment of infants at the FMs stage were observed.χ2 test was used to compare the correlation between UU colonization and neurodevelopment of infants at the FMs phase,and logistic regression was used to analyze the risk/protective factors.The UU colonization group was further divided into high or low UU-DNA copy number subgroups according to the best cut-off point of the ROC curve.Neurodevelopment was ob-served in infants at the FMs phase.Result:There were significant differences in maternal UU fixation group in terms of premature rupture of membranes(PROM),vaginal delivery,and history of miscarriages compared with the UU non-fixation group(P<0.05),and significant differences in infant's age,birth weight,neonatal asphyxia,neonatal hypoxic-isch-emic encephalopathy(HIE),and intraventricular hemorrhage compared with the UU non-fixation group(P<0.05).χ2 test results showed that perinatal maternal lower genital tract UU colonization would adversely affect the neurodevelopment of infants at the FMs phase(P<0.05).Binary ordered logistic multifactorial analysis showed that neonatal asphyxia and HIE were independent risk factors for abnormal neurodevelopment at the FMs phase(P<0.05),while the effect of UU colonization on the neurodevelopment of infants at the FMs phase was not significant(OR=0.251,95%CI 1.913-5.786).With an increase in the number of UU-DNA cop-ies in the maternal lower genital tract during the perinatal period(UU≥3.15×104 copy/ml)the risk of abnor-mal neurodevelopment in infants at the FMs phase increased.Conclusion:Perinatal maternal lower genital tract UU colonization is not an independent risk factor for abnor-mal neurodevelopment during the restless motor phase,but UU colonization can adversely affect neurodevelop-ment,and high UU-DNA copy values are positively associated with abnormal neurodevelopment during the fidget movements phase of infants.
