Talaromyces marneffei infection after organ transplantation:challenges and countermeasures
10.12464/j.issn.1674-7445.2025178
- VernacularTitle:器官移植术后马尔尼菲篮状菌感染:挑战与应对策略
- Author:
Shanda LI
1
;
Yuxiang CHEN
;
Haoran SHI
;
Xiaojie MA
;
Tao LI
;
Hongtao JIANG
Author Information
1. 570100 海口,海南医科大学第二附属医院肾移植科
- Publication Type:Journal Article
- Keywords:
Organ transplantation;
Talaromyces marneffei;
Fungal infection;
Invasive;
Metagenomic next-generation sequencing;
Immunosuppression;
Macrophage;
Amphotericin B
- From:
Organ Transplantation
2025;16(5):805-811
- CountryChina
- Language:Chinese
-
Abstract:
Talaromyces marneffei is a rare opportunistic pathogen.Talaromyces marneffei infection is characterized by insidious onset,atypical clinical manifestations,low early diagnosis rate,and high misdiagnosis and fatality,and has received widespread attention in recent years.Organ transplant recipients become a high-risk group for Talaromyces marneffei infection due to postoperative immunosuppressive therapy.Metagenomic next-generation sequencing,targeted antifungal therapy,and immunosuppression regimen adjustment are key to improving the prognosis of Talaromyces marneffei infection patients.This article reviews the epidemiology,pathogenesis,diagnosis and treatment of Talaromyces marneffei infection in organ transplant recipients,explores current challenges and future research directions,and aims to inform the diagnosis and treatment of Talaromyces marneffeiinfection.
