Clinical outcomes analysis of nonobstructive azoospermia patients associated with mumps orchitis undergoing microdissection testicular sperm extraction and intracytoplasmic sperm injection
10.3760/cma.j.cn101441-20200313-00129
- VernacularTitle:腮腺炎性睾丸炎非梗阻性无精子症患者行同周期显微睾丸取精结合卵胞质内单精子显微注射技术的临床结局分析
- Author:
Liang ZHOU
1
;
Jianhua SUN
;
Xingzhe JI
;
Dangxia ZHOU
;
Ming GAO
;
Xiang LIU
;
Lei WANG
;
Zhou ZHANG
;
Moqi LYU
;
Yixin LI
;
Jie YANG
;
Wenhao SHI
Author Information
1. 西北妇女儿童医院生殖中心，西安 710003
- Publication Type:Journal Article
- Keywords:
Nonobstructive azoospermia;
Mumps orchitis;
Microdissection testicular sperm extraction;
Intracytoplasmic sperm injection
- From:
Chinese Journal of Reproduction and Contraception
2020;40(11):927-931
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical outcome of microdissection testicular sperm extraction (microTESE) combined with intracytoplasmic sperm injection (ICSI) in patients with nonobstructive azoospermia (NOA) associated with mumps orchitis.Methods:The clinical data of NOA patients who underwent microTESE from December 2013 to October 2019 in the ICSI treatment cycle in Assisted Reproduction Center, Northwest Women and Children's Hospital were collected. All the patients who had a history of mumps were divided into two groups according to whether they had mumps orchitis or not. The clinical outcomes after the implementation of microTESE combined with ICSI were compared.Results:A total of 52 NOA patients were finally collected in the present study and 26 patients successfully processed sperm retrieval, the total sperm retrieval rate (SRR) was 50.0% (26/52). The SRR was 94.4% (17/18) in ornitis group, and 26.5% (9/34) in non-ornitis group. The difference between the two groups was statistically significant ( P<0.001). ICSI treatment was tried in sperm patients, and the clinical pregnancy rate was 61.5% (16/26). There was no statistically significant difference in the clinical pregnancy rate and the early pregnancy abortion rate between ornitis group and non-ornitis group [58.5% (10/17) vs. 66.7% (6/9), P=0.696; 20.0% (2/10) vs. 16.7% (1/6), P=0.868]. In the laboratory data, the difference of two pronucleus rate between orchitis group and non-orchitis group was statistically significant (73.9% vs. 57.0%, P=0.006), while the difference of high-quality embryo rate between the two groups was not statistically significant (44.2% vs. 56.8%, P=0.144). Conclusion:The SRR of NOA patients with mumps orchitis was higher that of out ornitis. And good results can be expected when microTESE and ICSI treatment are performed at the same period.
