Serologic Testing and Risk Factor Analysis of Human Cytomegalovirus Infection in Children Aged 0～1 Years in Hohhot Region,2020～2022
10.3969/j.issn.1671-7414.2025.05.029
- VernacularTitle:2020～2022年呼和浩特地区0～1岁儿童巨细胞病毒感染的血清学检测及危险因素分析
- Author:
Xiaoyan PANG
1
;
Xiaohua WANG
1
;
Yunpeng JI
1
;
Lu LI
1
;
Yuexin SONG
1
;
Xueyuan ZHOU
1
Author Information
1. 内蒙古自治区妇幼保健院遗传优生科/医学遗传学内蒙古自治区工程研究中心,呼和浩特 010020
- Publication Type:Journal Article
- Keywords:
human Cytomegalovirus infection;
serological test;
breast-feeding;
vaginal parturition;
risk factor
- From:
Journal of Modern Laboratory Medicine
2025;40(5):153-157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the serologic prevalence and infection status of Cytomegalovirus(CMV)in children aged 0～1 years,and explore the risk factors of CMV infection for clinical reference.Methods The data of 4 938 children aged 0～1 years who underwent chemiluminescence enzyme immunoassay for TORCH in Department of Inpatient and Department of Pediatrics Outpatient of Maternal and Child Health Hospital of Inner Mongolia from January 2020 to December 2022 were retrospectively analyzed to understand the seroprevalence of human CMV(HCMV)among children in the region,and analyzed the risk factors associated with HCMV infections by combining the results of laboratory tests and clinical information.Results In 4 938 children,the total antibody positivity rate was 94.01%(4 642/4 938),the total IgG antibody positivity rate was 93.86%(4 635/4 938),the total IgM antibody positivity rate was 8.10%(400/4 938),and the positive rate of the two simultaneous detections was 7.96%(393/4 938).The difference in HCMV-IgG and HCMV-IgM antibodies positivity rates beteen different age groups were statistically significant(χ2=36.350,1 043.199,all P<0.05),and the differences in HCMV-IgG and IgM antibodies between boys and girls were not statistically significant(χ2=0.215,1.184,all P＞0.05).According to univariate analysis,the breast-feeding and vaginal delivery rates in the infected group were higher than those in the control group,and the differences in feeding and birth methods were statistically significant(χ2=10.777,5.725,all P<0.05).Multifactorial analysis found that breast-feeding and transvaginal delivery were independent risk factors for HCMV infection,and the differences was statistically significant(Wald χ2=6.247,10.057,all P<0.05).Conclusion The serologic antibody positivity rate of HCMV in children within 1 year of age is as high as 94.01%,and infants aged 3 months to 6 months are most susceptible to infection.Breastfeeding and transvaginal delivery are independent risk factors for HCMV infection in children within 1 year of age.
