Application of ooplasmic transfer in assisted reproduction
- VernacularTitle:卵胞质移植技术在辅助生殖中的应用
- Author:
Shuai LIU
1
;
Zhiheng CHEN
1
;
Caiqi MA
1
;
Yunhao LIANG
1
;
Hui WANG
1
;
Li YANG
1
;
Yu JIANG
1
;
Ling SUN
1
Author Information
- Publication Type:Journal Article
- Keywords: Ooplasmic transfer; Mitochondria; Oocyte contents; Apoptosis; Epigenetic modifications; Assisted reproduction
- From: Chinese Journal of Reproduction and Contraception 2020;40(10):805-808
- CountryChina
- Language:Chinese
- Abstract: One of the great challenges in assisted reproduction today is the management of cases with poor-quality oocytes. Ooplasmic transfer (OT) has been used with the aim of augmenting embryo viability in patients with multiple implantation failures, usually associated with developmentally compromised oocytes. The justification for the technique was that the ooplasm from the donor contained beneficial components lacking in the recipient's oocytes, and that the transfer of these components to the recipient's oocytes would result in normal growth and viability. This review focuses on concerns regarding its use in assisted reproduction, like mitochondrial functioning, mitochondrial DNA heteroplasmy, regulation of apoptosis, cleavage division, epigenetic modifications, oocyte contents and mRNA which are the factors affecting oocytes due to mixing of two entities. The applications, efficacy and adverse effects of OT techniques in human are summarized.
