Progress in Application of Vitamin D in Ulcerative Colitis
10.3969/j.issn.1008-7125.2025.01.011
- VernacularTitle:维生素D在溃疡性结肠炎中的应用进展
- Author:
Ziying HU
1
;
Hongliang GAO
1
Author Information
1. 新疆医科大学第一附属医院消化病二科(830054)
- Publication Type:Journal Article
- Keywords:
Colitis,Ulcerative;
Vitamin D;
Vitamin D Receptors;
Therapy
- From:
Chinese Journal of Gastroenterology
2025;30(1):56-61
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis(UC)is a chronic,recurrent intestinal inflammatory disorder.In recent years,the role of vitamin D in the treatment of UC has attracted widespread attention.Studies have demonstrated that vitamin D exerts therapeutic effects through multiple mechanisms including maintaining intestinal barrier,regulating immune cells and inflammatory factors,modulating gut microbiota,and regulating gene expression.Clinical studies have found that vitamin D supplementation can improve UC symptoms,alleviate inflammatory response,and enhance patients'quality of life.Additionally,there are differences in efficacies when vitamin D is combined with different drugs.This article reviewed the research progress on the mechanism and supplementation dosage of vitamin D in the treatment of UC,as well as its role in disease assessment and clinical significance.
