Analysis of drug sensitivity and clinical characteristics of patients with blood Streptococcus infection from 2017 to 2022
10.13602/j.cnki.jcls.2025.10.06
- VernacularTitle:2017-2022年血流感染患者链球菌药物敏感性及临床特征分析
- Author:
Qiuxia GE
1
;
Wenying XIA
1
;
Weijuan SONG
1
;
Yanfei LU
1
;
Yuqiao XU
1
;
Kun FAN
1
Author Information
1. 南京医科大学第一附属医院检验学部&国家医学检验临床医学研究中心分中心,南京 210029
- Publication Type:Journal Article
- Keywords:
Streptococcus;
bloodstream infection;
susceptibility;
vancomycin
- From:
Chinese Journal of Clinical Laboratory Science
2025;43(10):748-752
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of Streptococcus,sensitivity to commonly used antibiotics,and prognosis of the patients with bloodstream infections,and provide evidence for early diagnosis and selection of antibiotics.Methods The Streptococci i-solated from the blood samples of the First Affiliated Hospital of Nanjing Medical University from 2017 to 2022 were collected and di-vided into α-and β-hemolytic Streptococci according to the type of hemolysis.Their sensitivity to commonly used antibiotics was ana-lyzed.The differences in clinical data and prognosis between the two groups were also compared.Results A total of 314 strains of Streptococcus were isolated from 305 patients,including 270 strains of α-hemolytic Streptococcus and 44 β-hemolytic Streptococcus.The results of the drug sensitivity test showed that the proportion of Streptococcus strains with a diameter of 17-19 mm in the inhibition zone of vancomycin increased year by year.The positive alarm time of blood culture for β-hemolytic Streptococcus was significantly shorter than that for α-hemolytic Streptococcus(P＜0.001).Using 10.5 hours as the diagnostic threshold could assist in distinguishing blood-stream infections caused by α-and β-hemolytic Streptococcus.The overall mortality rate of patients with streptococcal bloodstream infec-tion was 15.1％,and there was no statistically significant difference in the mortality rate between the two groups(P=0.813).Conclu-sion The main Streptococcus causing bloodstream infections in our hospital is α-hemolytic Streptococcus.There are differences in the antimicrobial sensitivity and clinical characteristics among patients with different streptococcal bloodstream infections.The positive a-larm time of blood culture can assist in distinguishing the type of streptococcal bloodstream infections.In addition,the diameter of the inhibition zone of vancomycin against Streptococcus has drifted towards the breakpoint of drug resistance.
