Research progress of long non-coding RNAs in folliculogenesis and related diseases

VernacularTitle:长链非编码RNA在卵泡发育及其相关疾病中的研究进展
Author: Jiayu HUANG ¹ ; Yanzhi DU ¹
Author Information

1. 上海交通大学医学院附属仁济医院生殖医学中心，上海市辅助生殖与优生重点实验室200135
Publication Type:Journal Article
Keywords: Long non-coding RNAs; Polycystic ovary syndrome; Premature ovarian insufficiency; Folliculogenesis
From: Chinese Journal of Reproduction and Contraception 2020;40(11):958-963
CountryChina
Language:Chinese
Abstract: Long non-coding RNAs (LncRNAs) are large and diverse class of non-protein-coding transcripts that are longer than 200 nucleotides. LncRNA plays an important role in folliculogenesis and related diseases including polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI). LncRNAs regulate various follicular biological processes, including cumulus expansion, oocyte maturation, luteinization, etc. In women with PCOS, LncRNAs are also involved in cell proliferation, cell invasion, cell apoptosis, endocrine and metabolism actions. Here, we review the LncRNAs which may contribute to the occurrence of PCOS and POI. This article may provide potential biomakers and therapeutic targets thus shed new light to understand the underlying mechanisms of folliculogenesis and related diseases.