Clinical outcomes of luteal phase stimulation for in vitro fertilization/intracytoplasmic sperm injection treatment in poor ovarian responders
10.3760/cma.j.cn101441-20190904-00400
- VernacularTitle:卵巢低反应患者黄体期促排卵行体外受精/卵胞质内单精子显微注射助孕临床结局分析
- Author:
Lina GUO
1
;
Nan WANG
1
;
Cuiting LYU
1
;
Xinzhuan JIA
1
;
Cui DONG
1
Author Information
1. 河北医科大学第四医院，石家庄 050011
- Publication Type:Journal Article
- Keywords:
Poor ovarian response;
Luteal phase stimulation;
Frozen-thawed embryo transfer
- From:
Chinese Journal of Reproduction and Contraception
2020;40(9):756-760
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical outcomes of luteal phase stimulation (LPS) for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment in patients with poor ovarian response (POR). Methods:Retrospective analysis was conducted on the clinical, laboratory data and clinical pregnancy outcome of frozen-thawed embryo transfer of 134 POR patients using LPS protocol for IVF/ICSI treatment in Reproductive Medical Center of the Fourth Hospital of Hebei Medical University from June 2013 to December 2018.Results:Totally 142 IVF/ICSI cycles were completed in 134 POR patients. About 5.63% (8/142) cycles cancelled due to unsuitable follicle, 7.75% (11/142) were failed to obtain oocyte and 37.32% (53/142) had unsuitable embryos for freezing, the total cancellation rate reached 50.70%. The duration of human menopausal gonadotropin (hMG) used was (10.04±3.51) d and the used dosage was (2 330.00±890.48) IU. In 24.64% (35/142) cycles, progesterone decreased to less than 1 μg/L on the trigger day. The number of oocytes retrieved, M II oocytes, two pronucleus (2PN), available embryos, high-quality embryos were 3.13±2.60, 2.98±2.25, 2.17±1.69, 2.04±1.53, 1(0.2), respectively. The rates of oocytes retrieved, M II oocytes, 2PN, available embryos, high-quality embryos were 76.04% (419/551), 86.63% (363/419), 69.97% (254/363), 91.34% (232/254) and 46.06% (117/254), respectively. Before June 2016, high-quality embryos were frozen, and poor-quality embryos were cultured, the blastocyst formation rate was 15.22% (7/46). After June 2016, all available embryos were cultured, the blastocyst formation rate was 41.98% (55/131). In the following frozen-thawed embryo transfer cycles, the clinical pregnancy rate per transfer cycle was 41.67% (25/60), the abortion rate was 44.00% (11/25), and the live birth rate was 23.33% (14/60). Conclusion:The cancellation rate of LPS protocol was high in POR patients. If there were frozen embryos for transfer, the clinical pregnancy rate would be satisfied, but the abortion rate was high.
