Clinical Efficacy of Qingchi San for Mild-to-Moderate Active Ulcerative Colitis:A Retrospective Cohort Study
10.14148/j.issn.1672-0482.2025.1282
- VernacularTitle:青赤散治疗轻中度活动期溃疡性结肠炎临床疗效的回顾性队列研究
- Author:
Zhenghua ZHOU
1
;
Fanfan QU
;
Jianbin JI
;
Hongchang KANG
;
Chunyan WANG
;
Hui ZHANG
Author Information
1. 天津中医药大学第一附属医院,天津 300381;国家中医针灸临床医学研究中心,天津 300381
- Publication Type:Journal Article
- Keywords:
ulcerative colitis;
Qingchi San;
clinical efficacy;
bleeding time;
inflammation level;
cohort study
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(10):1282-1287
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To retrospectively analyze the clinical efficacy of Qingchi San in the treatment of mild-to-moderate ul-cerative colitis.METHODS A retrospective analysis was conducted on 221 ulcerative colitis patients treated at the Gastroenterology Department of First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from December 2014 to February 2024.Participants were divided into an observation group(n=121)and a control group(n=100).The control group received oral me-salazine,while the observation group received Qingchi San enema in addition to the control group's treatment.Both groups received a 4-week course of treatment.The two groups were compared in terms of clinical efficacy,clinical remission rate,TCM syndrome score,time to intestinal bleeding remission,and changes in inflammatory markers(C-reactive protein,erythrocyte sedimentation rate,and white blood cells)and coagulation markers(platelets and D-dimer).RESULTS After treatment,the total effective rate and clinical remission rate in the observation group were significantly higher than those in the control group(P<0.05,P<0.01).The TCM syn-drome scores for each item(diarrhea,abdominal pain,bloody stools with mucus,and tenesmus)in the observation group were signifi-cantly improved compared with those in the control group(P<0.01).The time to intestinal bleeding remission in the observation group was significantly shorter than that in the control group(P<0.01).C-reactive protein,erythrocyte sedimentation rate,and white blood cell count in the observation group were significantly decreased compared with those in the control group(P<0.05,P<0.01).There was no statistically significant difference in coagulation markers(platelets and D-dimer)between the two groups(P>0.05).No signif-icant treatment-related adverse reactions,such as liver and kidney damage,were observed during treatment.CONCLUSION Qing-chi San enema can improve the clinical efficacy of patients with mild-to-moderate ulcerative colitis,improve clinical symptoms,short-en bleeding time,and reduce inflammatory markers.
