Research progress of exosomes mediated intercellular communication in atherosclerosis
10.20039/j.cnki.1007-3949.2025.09.011
- VernacularTitle:外泌体介导的细胞间通讯在动脉粥样硬化中的研究进展
- Author:
Houbin CHU
1
;
Yunbo XIE
;
Guohua SONG
Author Information
1. 山东第一医科大学(山东省医学科学院)临床与基础医学院,山东省济南市 250000
- Publication Type:Journal Article
- Keywords:
exosomes;
atherosclerosis;
intercellular communication
- From:
Chinese Journal of Arteriosclerosis
2025;33(9):815-822
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes(Exo)are a class of extracellular vesicles with diameters ranging from 30 to 150 nm,capable of carrying proteins,lipids,RNA,and other bioactive molecules derived from donor cells.These nanoscale vesicles are released into the extracellular environment through complex secretory mechanisms and participate in various biological processes,playing a particularly important role in intercellular communication.Atherosclerosis(As)is a chronic inflam-matory vascular disease characterized by lipid deposition,inflammatory responses in the vessel wall,and luminal stenosis.Exosomes serve as crucial information carriers in the initiation and progression of As,influencing the disease course by modulating signaling pathways and gene expression.This article reviews the biogenesis of exosomes,discusses their func-tional roles in the progression of As,and explores their potential applications in clinical diagnosis and treatment.
