Effect of Zishen Anshen Tang combined with growth hormone on clinical outcomes of in vitro fertilization embryo transfer in patients with decreased ovarian reserve function
10.3969/j.issn.1006-5725.2025.20.019
- VernacularTitle:滋肾安神汤联合生长激素对卵巢储备功能减退患者体外受精-胚胎移植临床结局的影响
- Author:
Xuan LI
1
;
Rong LIN
;
Jiawen SU
;
Dun-min YE
Author Information
1. 广州中医药大学第三附属医院妇二科(广东 广州 510145)
- Publication Type:Journal Article
- Keywords:
Zishen Anshen Tang;
growth hormone;
decreased ovarian reserve function;
in vitro fer-tilization-embryo transfer;
clinical outcome
- From:
The Journal of Practical Medicine
2025;41(20):3283-3287
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of joint of Zishen Anshen Tang and growth hormone on the clinical outcomes of in vitro fertilization embryo transfer(IVF-ET)in patients with decreased ovarian reserve function(DOR).Methods A clinical trial was conducted on 108 DOR patients who underwent IVF-ET at the Reproductive Center of from January 2023 to August 2024.They were randomly assigned to a control group and a experimental group,each with 54.The control group was given growth hormone(GH),while the experimental group was additionally given Zishen Anshen Tang.The ovulation induction status,trigger day hormone levels,egg retrieval and embryo development,and clinical outcomes were compared.Results The duration of gonadotropin(Gn)use showed no great difference between two groups(P>0.05).The experimental group had lower Gn dosage,early LH peak rate,and luteinizing hormone(LH),higher estradiol(E2),progesterone(P),egg retrieval,2PN fertilization,available embryos,number of high-quality embryos on day 3,blastocyst formation rate,clinical pregnancy rate,and cumulative pregnancy rate,and a lower cycle cancellation rate than control group(P<0.05).Conclusion The joint of Zishen Anshen Tang and growth hormone for IVF-ET in DOR patients can improve their sex hormone and have a positive impact on clinical outcomes.
