Effect of endometriosis on follicular granulosa cells
10.3760/cma.j.cn101441-20191011-00451
- VernacularTitle:子宫内膜异位症对卵泡颗粒细胞的影响
- Author:
Jingqin MAO
1
;
Zhen HOU
1
;
Yugui CUI
1
;
Yundong MAO
1
Author Information
1. 南京医科大学第一附属医院/江苏省人民医院/江苏省妇幼保健院 生殖医学中心 210029
- Publication Type:Journal Article
- Keywords:
Endometriosis;
Granulosa;
Oxidative stress;
Folliculogenesis;
Energy metabolism
- From:
Chinese Journal of Reproduction and Contraception
2020;40(9):778-781
- CountryChina
- Language:Chinese
-
Abstract:
Patients with endometriosis are often associated with follicular growth retardation and oocyte maturation disorders, severely affecting patient fertility. In patients with endometriosis, the occurrence of apoptosis and oxidative stress events in granulosa cells, impaired cellular energy metabolism and steroid synthesis in patients with endometriosis may be the cause of abnormal follicular development and decreased oocyte quality. The inflammatory response caused by endometrioma, which afterwards leads excessive activation of follicles and fibrosis of the ovarian cortex, which directly reduces ovarian reserve. This article discusses the oxidative stress and apoptosis of follicle granulosa cells, steroid hormone synthesis, energy metabolism abnormality in patients with endometriosis, and explains the adverse effects of endometrioma on ovarian reserve from the perspective of inflammatory response.
