Efficacy of Kuntai capsule for treating ovarian reserve dysfunction: a Meta-analysis
10.3760/cma.j.cn101441-20190902-00394
- VernacularTitle:坤泰胶囊用于治疗卵巢储备功能低下有效性的Meta分析
- Author:
Baoli ZHANG
1
;
Lili ZHANG
1
;
Yuan YANG
1
;
Xiaoyan SUN
1
;
Liu YANG
1
;
Lirong WANG
1
;
Xuehong ZHANG
1
Author Information
1. 兰州大学第一医院生殖医学专科医院 730000
- Publication Type:Journal Article
- Keywords:
Ovarian reserve dysfunction;
Premature ovarian failure;
Ovarian function;
Kuntai capsule;
Meta analysis
- From:
Chinese Journal of Reproduction and Contraception
2020;40(9):750-755
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the efficacy of Kuntai capsule in the treatment of ovarian reserve dysfunction.Methods:CNKI, CBM, Wanfang database, VIP database, PubMed, EMbase database， and clinical trail registration (https://clinicaltrials.gov/) were searched from inception to July 2019 to collect randomized controlled trials (RCTs) about Kuntai capsule in treatment of ovarian reserve dysfunction. Literatures ware screened independently by two evaluators. After information extraction and risk assessment, meta analysis was performed by Rev Man 5.3 software.Results:A total of 14 radomized controlled trials （RCTs) involving 1191 patients were included. Meta analysis showed that there were significant differences in the number of antral follicle count (MD=0.83, 95% CI=0.32-1.35, P=0.001) between Kuntai capsule group and control group. There was no significant difference in serum anti-Müllerian hormone (AMH) level (MD=0.11, 95% CI=-0.04-0.26, P=0.14) and Kupperman score (MD=-2.67, 95% CI=-7.43-2.10, P=0.27) between the two groups. Conclusion:Kuntai capsule can effectively increase the number of antral follicle count for patients with ovarian reserve dysfunction, but there was no significant improvement in serum AMH level and it can not reduce the Kupperman score. However, due to the quantity and quality of the study, the above conclusions need to be verified by more research.
