Bumetanide improves the learning and memory abilities of rats in a model of hydrocephalus induced by kaolin
10.16557/j.cnki.1000-7547.2025.05.013
- VernacularTitle:布美他尼改善高岭土诱导脑积水模型大鼠的学习记忆能力
- Author:
Jun TAN
1
;
Chong ZHANG
1
;
Wei LEI
1
Author Information
1. 中国人民解放军北部战区总医院神经外科,沈阳 110016
- Publication Type:Journal Article
- Keywords:
bumetanide(BUM);
hydrocephalus;
kaolin;
learning and memory;
rat
- From:
Chinese Journal of Neuroanatomy
2025;41(5):643-647
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of bumetanide(BUM)on learning and memory in a rat model of hydro-cephalus induced by kaolin.Methods:A rat model of hydrocephalus was established by injecting kaolin into the lateral ventricle.Bumetanide was administered intranasally.The volume of the lateral ventricle was measured by magnetic resonance imaging,and changes in intracranial pressure were detected.The learning and memory ability of rats was evaluated by the novel object recognition test,and neuronal damage in the hippocampus was detected by Nissl staining.Results:Compared with the control group,the lateral ventricle expansion was more obvious,intracranial pressure was elevated,and the exploring novel object time was significantly decreased in the bumetanide treatment group.Nissl stai-ning showed neuronal damage.After bumetanide treatment,the volume of the lateral ventricle decreased,intracranial pressure decreased,the exploring novel object time increased,and neuronal damage was alleviated.Conclusion:Bu-metanide can alleviate kaolin-induced hydrocephalus in rats and improve learning and memory ability.
