Analysis of the factors influencing the clinical outcome of frozen euploid single blastocyst transfer
10.3760/cma.j.cn101441-20200228-00091
- VernacularTitle:整倍体单囊胚冷冻移植临床结局影响因素分析
- Author:
Jiazhou CHEN
1
;
Xiandong PENG
1
;
Lu LI
1
;
Xiaoxi SUN
1
Author Information
1. 上海集爱遗传与不育诊疗中心，复旦大学附属妇产科医院 200011
- Publication Type:Journal Article
- Keywords:
Embryo transfer;
Pregnancy outcome;
Euploid blastocyst;
Blastocyst quality;
Blastocyst forming time
- From:
Chinese Journal of Reproduction and Contraception
2020;40(7):560-565
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To find out the key factors that affect the clinical outcome of euploid single blastocyst transfer.Methods:This retrospective study included 956 patients' clinical data of frozen euploid single blastocyst transfer cycles for preimplantation genetic testing (PGT) in Shanghai Ji Ai Genetics and IVF Institute from January 2014 to January 2018. According to the outcome of transplantation, the patients were divided into pregnancy group ( n=509) and non-pregnancy group ( n=447), and the clinical data between the two groups were compared to screen out the key factors affecting the pregnancy rate of transplantation; at the same time, the pregnancy group was further divided into live birth subgroup and miscarriage subgroup, and the clinical data between the two subgroups were compared and the significant factors affecting the abortion were screened by logistic regression. Results:The endometrial thickness of pregnancy group was significantly thicker than that of non-pregnancy group [9(8,10) mm vs. 8(8,10) mm] ( P=0.006); the clinical pregnancy rate and the live birth rate of blastocyst with good quality were significantly higher than those with poor quality (59.2% vs. 46.3%, 50.2% vs. 37.7%) ( P=0.001). In addition, compared with miscarriage subgroup, blastocyst development time was a risk factor of abortion, and the OR value was 0.536 (95% CI=0.309-0.929). Conclusion:In the frozen embryo transfer cycles of single euploid blastocyst, the thicker endometrium, the faster development and the higher score of blastocyst are the key factors for the success of the implantation. In the process of maintaining the late pregnancy, the faster development of blastocyst (D5) has a higher live birth rate and a lower miscarriage rate.
