Effect of dexamethasone on postoperative cognitive dysfunction in neurosurgical patients
10.3969/j.issn.1006-7795.2025.05.011
- VernacularTitle:地塞米松对神经外科患者术后认知功能障碍的影响
- Author:
Xinman YE
1
;
Minyu JIAN
1
;
Ruquan HAN
1
Author Information
1. 首都医科大学附属北京天坛医院麻醉科,北京 100070
- Publication Type:Journal Article
- Keywords:
dexamethasone;
glucocorticoid;
neurosurgery;
postoperative cognitive dysfunction;
perioperative neurocognitive disorders;
cognitive changes
- From:
Journal of Capital Medical University
2025;46(5):833-838
- CountryChina
- Language:Chinese
-
Abstract:
Postoperative cognitive dysfunction(POCD)is a common complication of anesthesia and surgery.With advances in neurocognitive science,POCD has been classified under the category of perioperative neurocognitive disorders(PND).However its diagnostic criteria have not been standardized.Patients undergoing neurosurgery often have pre-existing mild cognitive impairment.Moreover cognitive impairment can be directly exacerbated by structural and functional brain damage resulting from surgical procedures,which is significantly different from other surgical procedures.Dexamethasone,a commonly used neurosurgical agent,exerts neuroprotective effects through anti-inflammation,reduction of cerebral edema,and lowering of intracranial pressure.While some studies have indicated dexamethasone's potential to mitigate POCD in non-neurosurgical settings,its performance and underlying mechanisms in neurosurgical procedures remain unclear.After a systematic search,only one randomized controlled trial for microvascular decompression was identified that directly addressed this issue.This article aims to address the research gap concerning the relationship between dexamethasone and POCD in neurosurgery procedures to provide insights and implication for future investigations.
