Effects of desflurane on the quality of the anesthesia emergence period in patients undergoing transnasal pituitary adenoma resection:a randomized controlled study
10.3969/j.issn.1006-7795.2025.05.008
- VernacularTitle:地氟烷对鼻内镜下垂体腺瘤切除术患者麻醉恢复质量的影响:一项随机对照研究
- Author:
Yuxuan FU
1
;
Yang ZHOU
;
Yidan CUI
;
Youxuan WU
;
Yun YU
;
Ruquan HAN
Author Information
1. 首都医科大学附属北京天坛医院麻醉科,北京 100070
- Publication Type:Journal Article
- Keywords:
perioperative management;
desflurane;
propofol;
pituitary adenoma;
neurosurgery;
quality of perioperative recovery
- From:
Journal of Capital Medical University
2025;46(5):812-819
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of desflurane inhalation anesthesia versus propofol total intravenous anesthesia on postoperative recovery quality in patients undergoing endoscopic transnasal pituitary adenoma resection,and to provide evidence-based recommendations for optimizing anesthetic management in this surgical population.Methods This single-center,prospective,randomized controlled trial enrolled 112 patients scheduled for endoscopic transnasal pituitary adenoma resection,who were randomly assigned to either the desflurane group(n=56)or the propofol group(n=56).The desflurane group received desflurane[0.7-1.0 minimum alveolar concentration(MAC)]combined with remifentanil for anesthesia maintenance,whereas the propofol group received propofol(4-6 mg·kg-1·h-1)with remifentanil.The primary outcome was defined as the time from discontinuation of anesthetics to achieving an Aldrete score of 9.Secondary outcomes included emergence time,extubation time,and incidences of postoperative agitation and vomiting.Results Patients receiving desflurane achieved an Aldrete score of 9 significantly faster than those in the propofol group(13.0 min vs 16.5 min,P=0.003).Similarly,both emergence time(14.0 min vs 16.5 min,P=0.009)and extubation time(13.0 min vs 16.5 min,P=0.003)were significantly shorter in the desflurane group.However,the desflurane group had higher incidences of postoperative agitation(17.9%vs 3.6%,P=0.015)and vomiting(19.6%vs 5.4%,P=0.022).No significant difference was observed in severe agitation rates or 24 h postoperative recovery quality[Quality of Recovery-15(QoR-15)scores]between groups.Conclusion Desflurane anesthesia significantly accelerates postoperative recovery in patients undergoing endoscopic transnasal pituitary adenoma resection,however,it may increase risks of mild agitation and vomiting.In clinical applications,it is necessary to balance recovery benefits against potential adverse effects,and take targeted prophylactic measures.
