Advances in the role of circadian clock genes between circadian rhythms and depression
10.3969/j.issn.1002-0152.2025.09.009
- VernacularTitle:生物钟基因调控昼夜节律影响抑郁症研究进展
- Author:
Keyi WEN
1
;
Yunyan ZHANG
1
;
Fangyi WANG
1
;
Ying ZHOU
1
;
Xiangyu LI
1
;
Linglu MA
1
;
Yutong WANG
1
;
Yixiao FU
1
Author Information
1. 重庆医科大学附属第一医院精神科重大脑疾病与衰老教育部重点实验室(重庆 400016)
- Publication Type:Journal Article
- Keywords:
Clock genes;
Depression;
Circadian rhythm;
Sleep disorders;
DNA methylation;
SNPs;
Gene ex-pression regulation
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(9):565-570
- CountryChina
- Language:Chinese
-
Abstract:
Depression and circadian rhythms exhibit bidirectional interactions,suggesting a close association with the biological clock system.The biological clock in the suprachiasmatic nucleus of the hypothalamus is regulated by circadian genes.Recent clinical and basic research has revealed multifaceted associations between depression and circadian genes.For instance,significant phase abnormalities in BMAL1,PER2,and PER3 were detected in brain tissue from depressed patients,while plasma levels of CRY1,ARNTL,and PER1 proteins showed marked reduction,demonstrating good diagnostic value.Mice with CLOCK and BMAL1 knockouts exhibited depression-like behaviors.Single nucleotide polymorphisms(SNPs)in genes such as PER1 and PER3 directly influence depression susceptibility.Methylation levels of BMAL1,PER3,and CLOCK genes correlate closely with depressive symptoms.Antidepressant mechanisms like ketamine exert their effects by downregulating PER2 and other genes.This review summarizes the differential expression patterns of circadian clock genes in depression and associated therapeutic approaches,aiming to provide new theoretical foundations for precision diagnosis and personalized treatment strategies for depression.
