Research progress on mitochondrial dynamics in the pathogenesis of psychiatric disorders
10.3969/j.issn.1002-0152.2025.09.010
- VernacularTitle:线粒体动力学在精神疾病发病机制中的研究进展
- Author:
Xianqiang ZHANG
1
;
Jing XIONG
;
Denong LIU
;
Jitao LI
;
Tianmei SI
;
Yunai SU
Author Information
1. 山东省戴庄医院精神科(济宁 272051)
- Publication Type:Journal Article
- Keywords:
Mitochondrial dynamics;
Schizophrenia;
Depression;
Bipolar disorder;
Alzheimer disease;
Autism spectrum disorder;
Neuron
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(9):571-576
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the potential role of mitochondrial dynamics imbalance in the pathogenesis of various psychiatric disorders has attracted growing attention.Mitochondria regulate energy metabolism,oxidative stress,apoptosis,and neuronal function through dynamic processes such as fission and fusion.Disruption of these processes may impair synaptic function and neural network stability.In schizophrenia,depression,bipolar disorder,Alzheimer disease,and autism spectrum disorders,studies have reported dysregulated expression of mitochondrial fission-related proteins DRP1 and FIS1,as well as fusion-related proteins MFN1,MFN2,and OPA1,accompanied by structural and functional mitochondrial impairments,neuronal apoptosis,and synaptic loss.Evidence from clinical studies,animal models,and cell experiments further supports that these mitochondrial dynamics abnormalities are closely associated with cognitive deficits,emotional disturbances,and neurodegenerative changes.Although mitochondrial dynamic dysfunction alone cannot fully explain the onset of psychiatric disorders,it may represent a potential biological mechanism that offers new insights into disease mechanisms and provide a theoretical basis for developing targeted intervention strategies.
