Research progress on N-methyl-D-aspartic acid receptor hypothesis of schizophrenia and intervention drugs
10.3969/j.issn.1002-0152.2025.09.008
- VernacularTitle:精神分裂症认知功能缺陷N-甲基-D-天冬氨酸受体假说及干预药物研究进展
- Author:
Jinyang ZHAO
1
;
Jijun WANG
1
Author Information
1. 上海交通大学医学院附属精神卫生中心 脑电生理研究室(上海 200030)
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Cognitive dysfunction;
N-methyl-D-aspartate receptors;
Glycine;
Glycine plasma membrane transport proteins;
D-amino-acid oxidase;
Memantine
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(9):558-564
- CountryChina
- Language:Chinese
-
Abstract:
Currently,antipsychotics work through dopamine or serotonin system,and had limited effect on cognitive function.The hypothesis that the defects in the glutamate transmission and N-methyl-D-aspartic acid receptor(NMDAR)cause cognitive impairment has received attention,potentially serving as a promising target for improving cognitive function.Relevant pharmacotherapeutic approaches mainly include NMDAR co-agonists,glycine transporter 1(GlyT1)inhibitors,D-amino acid oxidase(DAAO)inhibitors and NMDAR antagonist.Current evidence from research suggests that GlyT1 inhibitors and DAAO inhibitors may be safe and more effective.
