Modulation of microglia by traditional Chinese medicine improves post-stroke depression
10.3969/j.issn.1006-5725.2025.18.023
- VernacularTitle:中药调控小胶质细胞改善卒中后抑郁的研究进展
- Author:
Qi LI
1
;
Jing GAO
;
Ming ZHANG
;
Xu ZHANG
;
Yachen FENG
;
Rui PAN
;
Chunxiao WANG
;
Qiongdi REN
Author Information
1. 河南中医药大学康复医学院(河南 郑州 450046);河南中医药大学第一附属医院康复诊疗中心(河南 郑州 450003)
- Publication Type:Journal Article
- Keywords:
post-stroke depression;
microglia;
traditional Chinese medicine;
regulatory mechanisms
- From:
The Journal of Practical Medicine
2025;41(18):2945-2952
- CountryChina
- Language:Chinese
-
Abstract:
Post-stroke depression(PSD),a common stroke complication characterized by depressed mood and diminished interest,severely affects patients'recovery and quality of life.Microglial abnormal activation and polarization play key roles in PSD pathogenesis,closely associated with neuroinflammation and imbalance in neu-rotransmitter metabolism.In contrast,traditional Chinese medicine(TCM)demonstrates unique multi-target and multi-level mechanisms:regulating microglial function,ameliorating post-stroke neuroinflammatory environments,and promoting neuroplasticity,thereby potentially alleviating PSD symptoms.This review summarizes TCM's effects on microglial activation/polarization states and its therapeutic advances in PSD,providing novel perspectives and strategies for clinical management.
