Relationship between the stages of diabetic retinopathy and the risk of lower extremity arterial disease in type 2 diabetes mellitus patients
10.3969/j.issn.1006-6187.2025.10.002
- VernacularTitle:2型糖尿病患者糖尿病视网膜病变分期与下肢动脉疾病风险相关性的研究
- Author:
Dan LIU
1
;
Xiaoxia SHI
;
Wei GUO
Author Information
1. 473000 南阳医学高等专科学校第一附属医院内分泌科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Diabetic retinopathy;
Stage;
Lower limb arterial disease
- From:
Chinese Journal of Diabetes
2025;33(10):727-732
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the stages of diabetic retinopathy(DR)and the risk of arterial disease in lower limbs(LEAD)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 70 patients with T2DM admitted to The First Affiliated Hospital of Nanyang Medical College from March 2021 to October 2023 were selected as the research object.According to whether or not there was LEAD,they are divided into combined LEAD(LEAD,n=69)group and simple DR group(n=201).The clinical data and DR staging between two groups were compared.The correlation between intima-media thickness of lower limb arteries and other indicators in T2DM patients was evaluated by Spearman analysis.The risk factors of T2DM patients complicated with LEAD were analysis by Logistic regression.The receiver operator characteristic(ROC)curve was drawn,and the prediction efficiency was evaluated by the area under the curve.Results The incidence of LEAD in 270 DR patients was 25.56%.The age,DM duration,homeostasis model assessment-insulin resistance(HOMA-IR),hemoglobin A1c(HbA1c),total cholesterol(TC),C-reactive protein(C-RP),interleukin-6(IL-6),fibrinogen(FIB),cystatin C(CysC)and DR stage in the LEAD group were higher than in the DR group(P<0.05).Spearman correlation analysis showed that the intima-media thickness of lower extremity arteries was positively correlated with age,DM duration,HOMA-IR,HbA1c,TC,C-RP,IL-6,FIB,CysC and DR stages(P<0.05).Logistic regression analysis showed that age(OR 3.271,95%CI 1.694～6.314),DM duration(OR 3.340,95%CI 1.730～6.448),HbA1c(OR 3.466,95%CI 1.795～6.691),C-RP(OR 3.408,95%CI 1.765～6.578)and DR staging(OR 3.607,95%CI 1.869～6.964)were all influencing factors for T2DM patients with LEAD.The ROC curve analysis results showed that the area under the curve of HbA1c,C-RP,DR staging,and their combination for predicting LEAD in T2DM patients were 0.780,0.783,0.761,and 0.925,respectively.Conclusions There is a close relationship between DR staging and the occurrence of LEAD in T2DM patients,and the combination of HbA1c,C-RP,and DR staging has a higher predictive power for LEAD in T2DM patients.
