Predictive value of body fat estimation formula of Navarra University in bone mineral density with type 2 diabetes mellitus patients
10.3969/j.issn.1006-6187.2025.10.005
- VernacularTitle:纳瓦拉大学体脂估算公式预测2型糖尿病骨质疏松价值的研究
- Author:
Xunan WU
1
;
Ziyan SUN
1
;
Xia DENG
1
;
Guoyue YUAN
1
Author Information
1. 212001 镇江,江苏大学附属医院内分泌代谢科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Osteoporosis;
Body fat estimation formula of Navarra University;
Adipose tissue
- From:
Chinese Journal of Diabetes
2025;33(10):745-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between body fat estimation formula of Navarra University(CUN-BAE)and bone mineral density(BMD)in patients with type 2 diabetes mellitus(T2DM)and its predictive value for osteoporosis(OP).Methods A total of 428 patients with T2DM who were hospitalized in the Department of Endocrinology and Metabolism,Affiliated Hospital of Jiangsu University were enrolled in this study between October 2017 and October 2023.All the patients were divided into simple T2DM group(n=226),osteopenia(OT,n=126)group and OP group(n=76)according to BMD.The general data and biochemical indexes were compared between the two groups.The value of CUN-BAE was calculated,and the BMD value was testedby dual-energy X-ray method.The correlation between CUN-BAE and other indexes was evaluated by Spearman correlation,and the influencing factors for OP was evaluated by Logistic regression in T2DM patients.The diagnostic efficacy of CUN-BAE was explored by receiver operating characteristic(ROC)curve in T2DM patients complicated with OP.Results CUN-BAE was higher in OP group than in T2DM and OT group(P<0.05).Spearman correlation analysis showed that CUN-BAE was negatively correlated with the values of L1,L2,L3,L4,L1～L4,L2～L4,femoral neck BMD,wards triangle BMD,greater trochanter BMD,total hip BMD and L1～L4 BMD T value(P<0.05).Logistic regression analysis showed that CUN-BAE was a influencing factor for OP in T2DM patients.ROC curve analysis showed that the area under the curve predicted by CUN-BAE for T2DM patients complicated with OP was 0.672.Conclusions CUN-BAE value were significantly elevated in T2DM patients with OP.CUN-BAE was valuable for predicting OP in T2DM patients.
