Advances in differentiating tuberculosis-infected from vaccinated animals
- VernacularTitle:结核病自然感染与疫苗免疫的鉴别诊断研究进展
- Author:
Yufeng FAN
1
;
Xiaojing CHANG
1
;
Xiujuan WU
1
;
Weifeng CHEN
1
;
Tingyi ZHU
1
;
Zengqiang LI
1
;
Xiaoying ZHU
1
;
Jian LIU
1
;
Luming XIA
1
;
Hongjin ZHAO
1
Author Information
- Publication Type:Journal Article
- Keywords: tuberculosis; natural infection; vaccination; differential diagnosis
- From: Chinese Journal of Zoonoses 2025;41(9):987-992
- CountryChina
- Language:Chinese
- Abstract: Tuberculosis is a zoonotic disease posing a substantial public health threat.Immunological diagnosis and vaccine im-munization are both necessary to control tuberculosis prevalence.However,the identical antigenic components in diagnostic reagents and vaccines hinder the use of animal vaccines and limit the specificity of clinical diagnosis in humans.Differentiating infected from vaccinated animals can overcome these problems.This article reviews the progress in differential diagnosis research from three as-pects:the diagnostic effects of antigens,methods for discovering new antigens,and screening of new host immune markers,to provide a theoretical basis for future research.
