Molecular characterization of enteric human adenovirus in children younger than 5 years old in China,2023
- VernacularTitle:2023年中国5岁以下儿童肠道腺病毒分子特征分析
- Author:
Mengjie DONG
1
;
Ruyi CHE
1
;
Guangping XIONG
1
;
Hong WANG
1
;
Jinsong LI
1
;
Xiaoman SUN
1
;
Lili LI
1
;
Jiaxin FAN
1
;
Xiaoping TANG
1
;
Wudi ZHANG
1
;
Dandi LI
1
Author Information
- Publication Type:Journal Article
- Keywords: enteric human adenovirus; genotype; acute gastroenteritis; molecular characteristics
- From: Chinese Journal of Zoonoses 2025;41(9):887-892
- CountryChina
- Language:Chinese
- Abstract: Enteric human adenovirus(HAdV),a common cause of acute viral gastroenteritis in children,frequently triggers spo-radic infections,nosocomial transmissions,and outbreaks in kindergarten settings.This study was aimed at investigating the molecular characteristics and genetic evolution of enteric HAdV among patients with acute gastroenteritis younger than 5 years in China,to pro-vide foundational data for disease prevention and control.A total of 8 074 stool samples were collected from hospitalized or outpatient children younger than 5 years with acute gastroenteritis in China during 2023.HAdV screening was conducted with real-time fluores-cence PCR.Positive samples were sequenced,then subjected to bioinformatics analysis including genotyping,homology assessment,and phylogenetic analysis with GenBank,BioAider,and MEGA11.0.A total of 370 samples(4.58%)tested positive for HAdV.Two enteric HAdV genotypes were identified:HAdV-F41(which predominated,at 98.09%)and HAdV-F40(1.90%).HAdV-F41 was the dominant genotype among patients with acute gastroenteritis younger than 5 years in China.Bioinformatics analysis indicated that the predominant HAdV lineages in China were lineage 1 and 2,whereas European lineage 3 showed no influence.Systematic and long-term surveillance of HAdV should help elucidate its diversity and evolutionary patterns in China,thereby providing scientific evi-dence for developing more effective prevention strategies.
